Peptide Skinjection™ Amplified Wrinkle-Fix Refillable Serum
Peter Thomas Roth Peptide Skinjection™ Amplified Wrinkle-Fix Refillable Serum scores 8.1/9.8 overall. It ranks highest in hydration efficacy (9.8) and low irritation risk (9.5).
✶ Hero ingredients
Silicone that smooths and protects
Lightweight oil that mimics skin's natural sebum
Lightweight humectant and solvent
Score breakdown
Scores last verified: July 2026
What makes Peter Thomas Roth Peptide Skinjection™ Amplified Wrinkle-Fix Refillable Serum stand out
Peter Thomas Roth Peptide Skinjection™ Amplified Wrinkle-Fix Refillable Serum is an excellent serum with an overall score of 8.1/9.8. Positioned in the premium bracket, it delivers a well-rounded formulation that balances efficacy with gentleness. The formula leads with Dimethicone, Squalane, Butylene Glycol — ingredients that support the skin barrier and moisture levels.
It performs well on hydration (9.8) and low irritation risk (9.5). On the flip side, active ingredient concentration is on the lighter side.
Is this right for you?
Great for
- ✓Dry or dehydrated skin — strong moisture-binding profile
- ✓Sensitive skin — low irritation risk with a gentle formulation
- ✓Safety-conscious shoppers — clean formulation with minimal flags
Key ingredients
- ✶Dimethicone
Softens and smooths — #2 in the INCI list
- ✶Squalane
Softens and smooths — #3 in the INCI list
- ✶Butylene Glycol
Draws in moisture — #4 in the INCI list
- ✶Glycerin
Draws in moisture — #5 in the INCI list
- ✶Saccharomyces Lysate
Works on your skin — #6 in the INCI list
What creators are saying
TikTokTikTok reviewers are enthusiastic about this peptide serum, praising its effectiveness at reducing the appearance of wrinkles and fine lines, particularly around smile lines and the forehead, while highlighting the convenient dual-applicator design and easy overnight application. They love that it works as a non-invasive alternative to injectables and feels satisfying to use, with the active ingredients like Argireline, Matrixyl, and niacinamide delivering visible results. This product seems to resonate most with anyone looking for an accessible, effective anti-aging solution without the commitment or cost of professional treatments.
Based on 3 creator reviewsFull ingredient list
35 ingredients — listed in INCI order (highest concentration first)
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Ingredient breakdown
- Softens and smooths9
- Draws in moisture5
- Works on your skin5
- Keeps the product fresh5
- Holds the formula together4
- Other ingredient3
- Formula balancers3
- Added colour1